Sphingosine 1-Phosphate as a Therapeutic Target in Heart Failure
نویسندگان
چکیده
منابع مشابه
Sphingosine 1-phosphate as a therapeutic target in heart failure: more questions than answers.
Sphingosine 1-phosphate (S1P) is a naturally occurring bioactive lysophospholipid that regulates immune responses and inflammatory processes in a variety of different organ systems, including the cardiovascular system. Within the cardiovascular system, S1P mediates cardioprotection following ischemia/reperfusion injury, cardiac remodeling, vascular tone, angiogenesis, and fibroblast migration, ...
متن کاملSphingosine kinase 1/sphingosine 1-phosphate signalling pathway as a potential therapeutic target of pulmonary hypertension.
Pulmonary hypertension is characterized by extensive vascular remodelling, leading to increased pulmonary vascular resistance and eventual death due to right heart failure. The pathogenesis of pulmonary hypertension involves vascular endothelial dysfunction and disordered vascular smooth muscle cell (VSMC) proliferation and migration, but the exact processes remain unknown. Sphingosine 1-phosph...
متن کاملApoptosis as a therapeutic target in heart failure.
HEART FAILURE, THE ULTIMATUM of various forms of myocardial disease, is associated with high mortality rate in this modern world (2). Multiple factors play important roles in the genesis of heart failure. The presence of left ventricular hypertrophy is a powerful predictor of the development of heart failure (3). It is believed that gradual deterioration of the hypertrophied left ventricle (LV)...
متن کاملEndothelium as a therapeutic target in heart failure.
Endothelium as a Therapeutic Target in Heart Failure Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 1998 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR.98.24.2652 1998;98:2652-2655 Circulation. http://circ.ahajournals.org/content/98/24/2652 World Wide Web at...
متن کاملMitochondria as a therapeutic target in heart failure.
Heart failure is a pressing public health problem with no curative treatment currently available. The existing therapies provide symptomatic relief, but are unable to reverse molecular changes that occur in cardiomyocytes. The mechanisms of heart failure are complex and multiple, but mitochondrial dysfunction appears to be a critical factor in the development of this disease. Thus, it is import...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation
سال: 2012
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.112.107797